Key Patient Counseling Points:
- Take after meals to lessen gastric irritation.
- Maintain adequate hydration during therapy.
- Patient should avoid alcohol or caffeine while taking allopurinol.
- Seek medical attention if signs and symptoms of myelosuppression, agranulocytosis (severe neutropenia), or Stevens-Johnson syndrome (flu-like symptoms, spreading red rash, or skin/mucous membrane blistering) occur.
Xanthine Oxidase Inhibitor; Antigout
Mechanism of Action:
Allopurinol decreases the production of uric acid by inhibiting the action of xanthine oxidase, the enzyme that converts hypoxanthine to xanthine and xanthine to uric acid.