Acetaminophen/Codeine: Tylenol with Codeine #3

Key Patient Counseling Points:

  • If using chronically, use a stool softener and/or laxative for preventing constipation.
  • May cause drowsiness; avoid driving or other tasks requiring motor coordination.
  • Avoid alcohol.

Class:

Opioid/Acetaminophen Combination Product. C-III

Mechanism of Action:

Acetaminophen is a central inhibitor of prostaglandin synthesis. It has no effects on platelets. Codeine is 3-methoxymorphine, a phenanthrene opioid with very low affinity for opioid receptors. Its analgesic activity appears to result from conversion to morphine.

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